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4.8
Rated 4.8 out of 5 stars
4.8 Stars (136 Reviews)
(Based on 136 reviews)

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*Sold Out - expected restock in March

This two-item duo consists of the Peptide Squad Serum and Hydro Relief Cream.

Launched in November 2023 and already a bestseller, Peptide Squad is the only serum on the market that utilizes all four key peptide classes for comprehensive anti-aging benefits.

Hydro Relief is our latest cream, a non-greasy yet deeply hydrating formula that strengthens the skin barrier and combats dryness and redness.

Key Benefits: anti-aging, deep hydration, skin barrier repair.

Key Ingredients: Copper tripeptide-1 (GHK-cu), Matrixyl 3000, Argireline, rice and soy peptides and amino acids, niacinamide, panthenol, jojoba esters.

We firmly stand behind the efficacy of our products, which is why we back them with an industry-leading 100-day Money Back Guarantee.

If you're not 100% happy, return the products within 100 days for a full refund. We'll even cover the return shipping. It's our commitment to ensure that you're completely satisfied with your Maelove journey.

Introducing

Peptide Duo

Double up on peptides

Peptide Duo features the best wrinkle fighting and hydrating peptides to tackle signs of aging, provide deep hydration, and protect your skin barrier.

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On US orders over $45

Free returns

Not completely happy? Returns are on us.

100-day happiness guarantee

Returns within 100 days receive a full refund

Tackle wrinkles from all angles with peptides that are actually science-based

Peptide Squad is the only serum on the market with peptides from all four wrinkle-fighting classes: Copper Tripeptide-1 (GHK-Cu), Matrixyl 3000, Argireline, and rice peptides. Hydro Relief contains soy peptides and rice bran extracts which help even out skin tone.


Peptides are powerfully hydrating and plant-based lipids seal in moisture

Peptide Squad features rice peptides and ceramides while Hydro Relief takes it a step further with soy peptides and rice amino acids to deeply hydrate skin. Plant-based lipids in Hydro Relief seal all the goodness in.


The right supporting cast helps with redness and long-term skin barrier support

Panthenol (provitamin B5) and niacinamide (vitamin B3) found in both products are powerful anti-inflammatories and enhance your body’s production of skin barrier lipids. Peptide Squad also contains anti-inflammatories allantoin and red algae, while Hydro Relief contains antioxidant and anti-inflammatory green tea and rosemary extracts.


Perfect texture so you'll want to use it everyday

Efficacy is one thing, but let’s be real, how a product feels matters too. Peptide Squad’s texture is light and absorbs quickly into the skin. Hydro Relief’s texture is rich, creamy, and smooth without feeling greasy or tacky.

When to use

Use The Duo in the morning and/or evening.


How to use

Apply a full dropper of Peptide Squad serum onto clean skin.

  • Gently massage it in until it is fully absorbed.
  • You may experience a slight numbing or tingling sensation initially, but that is normal.
  • After serums, apply Hydro Relief cream to seal serums and moisture in.
Use it with
  • Peptide Squad can be used alongside any other Maelove serum. If using with other serums, use after The Glow Maker Antioxidant Serum.
  • Maelove’s serums are designed to be applied in layers from the thinnest to thickest in texture.
Peptide Squad

Key Ingredients

Matrixyl 3000 (Palmitoyl tripeptide-1, palmitoyl tripeptide-7) - signal peptides that increase collagen production

Argireline (acetyl-hexapeptide-8) - neurotransmitter-inhibiting peptide that inhibits movement based expression lines (edited)

Copper peptides GHK-Cu (copper tripeptide-1) - carrier peptide that helps build collagen

Rice peptides - enzyme inhibitor peptide that inhibit collagen breakdown

Supporting Ingredients

Skin barrier supporting, anti-inflammatory, and hydrating ingredients:
Niacinamide, panthenol, hyaluronic acid, natural moisturizing factors, ceramides, jojoba oil, and botanical extracts and actives including allantoin, aloe, green tea, turmeric, red algae, polyphenols madecassoside (found in CICA), and bisabolol (found in chamomile).


Hydro Relief

Key Ingredients

Soy peptides - natural moisturizing factors that are also anti-aging

Rice amino acids - natural moisturizing factors that attract and bind water

Panthenol (provitamin B5) - anti-inflammatory (can relieve redness) and also a humectant that holds water to improve hydration

Niacinamide (vitamin B3) - anti-inflammatory, anti-aging, and stimulates natural production of ceramides to strengthen the skin barrier

Jojoba Esters - plant-derived wax from Jojoba shrub that can prevent water loss from skin with performance on par with petroleum

Squalane - plant-derived version of a natural lipid found in skin that helps “water-proof” the skin so that it can retain moisture

Shea Butter - emollient occlusive from nut of African Shea tree can incorporate into the skin barrier and support it to improve moisture retention

Oryza Sativa (Rice) Bran extract - natural moisturizing factors that are anti-aging and help even skin tone

Green Tea extract - anti-inflammatory and antioxidant

Rosemary extract - antioxidant and antimicrobial


Show all ingredients
4.8
Rated 4.8 out of 5 stars
Based on 136 reviews
Total 5 star reviews: 116 Total 4 star reviews: 12 Total 3 star reviews: 5 Total 2 star reviews: 3 Total 1 star reviews: 0
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136 reviews
  • J
    Jackie
    Flag of United States
    Verified Buyer
    Peptide Squad Collagen Renewal Serum
    Reviewing
    Peptide Squad Collagen Renewal Serum
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    5 Stars

    I'm enjoying this serum so far. I purchased 2 because it's always sold out. I've been using it for 3 weeks and I see a difference. I'm applying it after the Glowmaker Vitamin C serum.

  • J
    Jackie
    Peptide Squad Collagen Renewal Serum
    Reviewing
    Peptide Squad Collagen Renewal Serum
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    5 Stars

    I’m enjoying this serum so far. I purchased 2 because it’s always sold out. I’ve been using it for 3 weeks and I see a difference. I’m applying it after the Glowmaker Vitamin C serum.

  • T
    Tatiana
    Verified Reviewer
    Powered by Peptides Duo
    Reviewing
    Powered by Peptides Duo
    I recommend this product
    What are your skin concerns? Acne and blemishes, Fine lines and wrinkles, Dark spots
    How old are you? 25-34
    What is your skin type? Sensitive
    Product Standouts Unique, Great Ingredients
    Rated 5 out of 5 stars
    2 weeks ago
    Blown away

    This is only the first day of using this duo and I am already blown away. I have never been so happy with applying a skincare product! My face was instantly smooth and glowy! Let me also add that I really like Maelove as a company. Customer service was very responsive and helpful. They answered all of my questions thoroughly and thoughtfully, providing me with all the information and assurance I needed to make my purchase. To me this very important when purchasing products I am putting on my face. I will be a long time customer. Will update as I use the product more but I can already tell it will be great. 10/10 recommended.

  • DS
    Dina S.
    Verified Buyer
    Peptide Squad Collagen Renewal Serum
    Reviewing
    Peptide Squad Collagen Renewal Serum
    I recommend this product
    What are your skin concerns? Fine lines and wrinkles, Dark spots
    How old are you? 55+
    What is your skin type? Normal
    Product Standouts Easy To Use, Hydrating, Healing
    Rated 5 out of 5 stars
    2 weeks ago
    Seems to be working

    I’ve been using this for several weeks. I do believe my skin looks brighter and my fine lines look a little better.

    I also use the Fade Away which also has helped uneven skin tone.

    This product and the Moonlight Retinol combined with consistent use is reducing some signs of aging.

    It is a little expensive, but if I’m noticing results I will stick with it.

  • LD
    Liza D.
    Verified Buyer
    Peptide Squad Collagen Renewal Serum
    Reviewing
    Peptide Squad Collagen Renewal Serum
    I recommend this product
    What are your skin concerns? Oil control, Dark spots, Fine lines and wrinkles
    How old are you? 45-54
    What is your skin type? Combination
    Rated 5 out of 5 stars
    3 weeks ago
    It works!!!

    Very hydrating without being oily. Light and easy to apply and non irritating. I feel my skin is glowing. Highly recommend!

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For the Curious

Amino acids are the building blocks for proteins and peptides. Peptides are basically mini-proteins. To learn more about peptides, please see Peptide Squad pages (link here). Amino acids are peptide are natural moisturizing factors. Hydro Relief incorporates soy and rice peptides that in addition to having hydrating benefits, also provide anti-aging benefits and can even out skin tone.

Let’s dive deeper:

Amino acids and peptides are hygroscopic molecules (humectants) that play a role as natural moisturizing factors (NMFs) within corneocytes. Indeed, 50% of NMFs are amino acids (from the breakdown of protein filaggrin) while the remaining NMFs are salts such as lactates, urea, and electrolytes (Purnamawati et al. 2017). Inclusion of peptides and amino acids in serums and creams boost the levels of these natural moisturizers.

Additionally, soy and rice peptides are known as enzyme inhibitor peptides that have anti-aging activity. Studies show rice and soy peptides inhibit serine proteases such as matrix metalloproteinases (MMPs) that break up extracellular matrix proteins such as collagen, elastin and glycosaminoglycans (GAGs) (Schagen 2017, Ferreira 2020). Rice peptides additionally stimulate hyaluron synthase (hyaluronic acid is a GAG) as well as having anti-tyrosinase activity for hyperpigmentation to help even out skin tone (Schagen 2017). Rice oligos with Vitamin C in ampoules have also been tested in humans with positive findings (Escobar et al. 2020).

Particularly in East Asia, rice peptides have been used for thousands of years going back to ancient times when women in the royal court used rice water to maintain their skin. In modern times, due to these powerfully hydrating, skin tone evening, and anti-aging properties, soy and rice peptides have been widely used in skincare products in East Asia for decades.

In summer, humectants can draw in water from the surrounding humid environment, but in the winter when the air is dry, humectants mostly attract water from the underlying dermis which is supplied by blood vessels. Hence, they must be combined with emollients and occlusives so that the water attracted by the humectant does not evaporate but rather is held in by the water-proof barrier forming lipids. The lipids in Hydro Relief are plant-based emollients and occlusives with superior performance (Sethi et al. 2016).

Here is an added benefit of peptides some of you may not know - they are also super hydrating.

Peptide Squad features hydrating rice peptides while Hydro Relief takes it a step further with soy and rice peptides and amino acids.

Amino acids and peptides are natural humectants that attract moisture and hold onto it.

And we’ve boosted these natural qualities with a supporting cast of hydrating ingredients. Peptide Squad includes humectant hyaluronic acid, as well as skin identical ceramides that incorporate into your skin barrier.

To really seal in moisture, these are then topped with better-than-petroleum, plant-based emollients and occlusives in Hydro Relief that lock in that moisture.


PLANT-BASED LIPIDS SEAL IN MOISTURE BUT WITHOUT THE GREASINESS
For dry skin, ingredients such as petroleum jelly or mineral oil can be good moisturizers but the negative side effect is greasiness. In contrast, natural and plant based lipids like squalane, shea butter, and jojoba esters, have been scientifically shown to provide equal moisturization as petroleum but without the greasiness. They also feel great on the skin (read more on the science in our Obsessively Formulated section below).


THE RIGHT SUPPORTING CAST HELPS WITH REDNESS AND LONG-TERM SKIN BARRIER SUPPORT
Studies show that vitamins such as panthenol (provitamin B5) and niacinamide (vitamin B3) not only have humectant properties, but can actually enhance your body’s natural production of ceramides, cholesterol and fatty acids - lipids that form your natural skin barrier. Further, they are anti-inflammatory. Both Peptide Squad and Hydro Relief feature panthenol and niacinamide. Peptide Squad also contains anti-inflammatories allantoin and red algae, while Hydro Relief contains antioxidant and anti-inflammatory green tea and rosemary extracts. These powerful anti-inflammatories will keep the redness of dry skin at bay (read more on the science in our Obsessively Formulated section below).


PERFECT TEXTURE SO YOU'LL WANT TO USE IT EVERYDAY
The efficacy of ingredients is one thing, but let’s be real, the texture and how a product feels matters too. Peptide Squad serum delivers a supreme texture that’s pleasant to apply. Hydro Relief cream delivers a rich, smooth and luxurious feel that is not tacky or goopy or greasy, ensuring you have a great experience every time you use it. You’ll look forward to applying these two every day!

Plus, there are no synthetic dyes or fragrances because our ingredients are so pure, they don’t need cover-ups.

Dry skin in the winter is a common complaint as humidity drops and the skin barrier is insufficient to prevent significant moisture loss. A recent trend called “slugging” uses petroleum jelly (vaseline) to combat winter dryness. However, it is greasy and environmentally unfriendly. Can plant-based lipids form as good a moisture barrier as petroleum based products but without these down-sides? The science says yes and shows plant based lipids can have other benefits as well.

Let’s dive deeper:

Shea butter, jojoba esters and squalane are favored to function as emollients and occlusives not only for their natural benefits and functionality but also for superior skin-feel.

Shea butter is a fat extracted from the nut of the African shea tree (Butyrospermum parkii). 85-90% of the fatty acid composition of shea butter is stearic and oleic acids, and the rest is composed of linoleic, palmitic, and arachidic fatty acids. These naturally found long chain saturated fatty acids act not only as occlusives but as emollients, incorporating into the skin barrier and improving skin barrier repair and hydration. In addition to fatty acids, shea butter contains natural triterpenes that have anti-inflammatory action (Purnamawati et al. 2017).

Squalene is a natural component of sebum and one of the most common lipids produced by human skin cells. The amount of squalene produced naturally by the body decreases drastically after age 30 contributing to dry skin with aging. Squalane (with an ‘a’) is a saturated form of squalene derived from plants. Squalane mimics squalene and has the added advantage of being less susceptible to oxidation. This makes squalane an ideal choice for use in moisturizers. Further, it does not have an oily feel, is odorless, does not lead to acne, is antibacterial and is safe for sensitive skin (Sethi et al. 2016).

Jojoba is a shrub native to the Southwestern United States whose seeds contain a liquid wax oil that was first used for skin and hair conditioning and healing by Native Americans. This oil contains long straight-chain wax esters that are more similar in composition to whale oil than other vegetable oils making it a superior occlusive. In fact, in clinical studies, jojoba esters perform on par with petroleum based products at preventing trans-epidermal water loss making it an ideal plant-based alternative for petroleum (Oliphant et al. 2013).

Studies show that vitamins such as panthenol (provitamin B5) and niacinamide (vitamin B3) not only have humectant properties, but can actually enhance your body’s natural production of ceramides, cholesterol and fatty acids - lipids that form your natural skin barrier.

Further, they are anti-inflammatory. Both Peptide Squad and Hydro Relief feature panthenol and niacinamide. Peptide Squad also contains anti-inflammatories allantoin and red algae, while Hydro Relief contains antioxidant and anti-inflammatory green tea and rosemary extracts.

These powerful anti-inflammatories will keep the redness of dry skin at bay (read more on the science in What does it mean when a cream is called skin barrier supporting? below).

Moisturizers generally provide hydration with humectants, emollients, and occlusives. Humectants attract and hold water, while emollients and occlusives provide lipids that incorporate into your existing skin barrier and also form a film on top of the skin for added water holding support. However, they may also function in a second, more long-term way by promoting the production of endogenous ceramides, cholesterol and fatty acids that form your natural skin barrier. Vitamins, and in particular niacinamide (vitamin B3) and panthenol (provitamin B5) are two of the most proven ingredients that demonstrates this type of skin barrier supporting activity. They have been found to be particularly useful at supporting your skin barrier against winter dryness and reducing redness.

Let’s dive deeper:

Panthenol is not only an excellent humectant but it is also absorbed into the skin where it is converted into pantothenic acid which is hygroscopic. This is in part why panthenol is an excellent moisturizer. The other is that pantothenic acid is a constituent of coenzyme A which is a cofactor in the synthesis of fatty acids and sphingoplipids that strengthen the skin barrier (Proksh et al. 2017). It is one of the most time-tested ingredients in moisturizers shown in double-blind clinical trials conducted over several decades to be effective and safe at hydrating, repairing and restoring a damaged skin barrier (Proksch et al. 2017, Scott et al. 2022). It is also well tolerated in those with sensitive skin with winter xerosis (Nisbet et al. 2019). Along with niacinamide, panthenol was found to have anti-inflammatory action as well and significantly reduce facial redness due to winter xerosis in those with sensitive skin (Nisbet et al. 2019)

Niacinamide is one of the most well-studied and gold standard ingredients in moisturizers, and particularly in moisturizers that are anti-aging. It directly combats age-related declines in cofactors that are necessary for a strong skin barrier. In other words, it supports the long-term hydration of skin by helping kickstart the body’s natural skin barrier strengthening mechanisms that may have become faulty with aging (Matts et al. 2002). Niacinamide when applied to dry skin has been shown to increase levels of skin barrier lipids such as ceramides, free fatty acids, and cholesterol and to decrease trans-epidermal water loss (Tanno et al. 2008). Niacinamide also increases protein levels for collagen, keratin, fillaggrin, and involucrin which also experience age-related declines (Gehring 2004, Bissett et al. 2006). This is why Niacinamide can also combat fine lines and wrinkles (Bisset et al. 2006).

In addition to its ability to increase skin hydration in older subjects, niacinamide has proven to be an effective and superior ingredient in combating skin dryness in eczema patients and in winter xerosis (dry and scaly skin brought on by dry, winter environments). For instance, in a head-to-head study against white petroleum in the treatment of dry skin in eczema patients, a niacinamide containing moisturizer but not petroleum led to long-term decreases in trans-epidermal water loss across 8 weeks. Further, while skin hydration improved similarly for both the niacinamide containing moisturizer and petroleum immediately after application, superior hydration was seen at 4 weeks and 8 weeks with niacinamide (Soma et al. 2005). Hence, with continued use, a niacinamide containing moisturizer was superior to white petroleum at strengthening the skin barrier and combatting skin dryness long-term. Niacinamide has also been shown to improve hydration and alleviate skin dryness specifically in patients with winter xerosis (Gehring 2004, Nisbet et al. 2019).

Panthenol and niacinamide have additional desirable properties as anti-inflammatories. Modern moisturizers further aim to include additional antioxidant and anti-inflammatory ingredients such as botanical extracts. Dry skin leads to a weakened skin barrier and hence, allergens and microbes can penetrate leading to free radical damage and inflammation. Inflamed and dry skin is therefore a common complaint. The addition of antioxidant and anti-inflammatory ingredients in moisturizers can aid in combating free radical damage and treating the inflammation. Botanical extracts from green tea and rosemary incorporate phytocompounds that have naturally antioxidant and anti-inflammatory action found to be beneficial for skin health (Prasanth et al. 2019, Pomi et al. 2023).

Escobar S, Valois A, Nielsen M, Closs B, Kerob D (2021). “Effectiveness of a formulation containing peptides and vitamin C in treating signs of facial ageing: three clinical studies.” Int J Cosmetic Sci 43: 131-135.

Ferreira MS, Magalhaes MC, Sousa-Lobo JM, Almeida IF (2020). “Trending Anti-Aging Peptides.” Cosmetics 7: 91. Doi:10.3390/cosmetics7040091.

Purnamawati S, Indrastuti N, Danarti R, Saefudin T (2017). “The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review.” Clinical Medicine and Research 15(3-4): 75-87.

Schagen SK (2017). “Topical Peptide Treatments with Effective Anti-Aging Results.” Cosmetics 4: 16. Doi:10.3390/cosmetics4020016

Sethi A, Kaur T, Malhotra SK, Gambhir ML (2016). “Moisturizers: The Slippery Road.” Indian J Dermatol 61(3): 279-287.

Purnamawati S, Indrastuti N, Danarti R, Saefudin T (2017). “The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review.” Clinical Medicine and Research 15(3-4): 75-87.

Oliphant T. Harper R (2013). “Skin barrier protection with jojoba esters.” JAAD 68 (4) Supplement 1: AB37

Sethi A, Kaur T, Malhotra SK, Gambhir ML (2016). “Moisturizers: The Slippery Road.” Indian J Dermatol 61(3): 279-287.

Bissett DL, Oblong JE, Berge CA (2006). “Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance.” Dermatologic Surgery 31: 860-866

Gehring W (2004). “Nicotinic acid/ niacinamide and the skin.” J Cosmet Dermatol 3: 88-93.

Matts PJ, Oblong JE, Bissett DL (2002).“A review of the range of effects of niacinamide in human skin.” IFSCC5(4):285-289.

Nisbet SJ, Targett D, Rawlings AV, Qian K, Wang X, Lin CB, Thompson MA, Bulsara PA, Moore DJ (2019). “Clinical and in vitro evaluation of new anti-redness cosmetic products in subjects with winter xerosis and sensitive skin.’ Int J Cosmet Sci 41: 534-547.

Pomi FL, Papa V, Borgia F, Vaccaro M, Allegra A, Cicero N, Gangemi S (2023). “Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases.” Antioxidants 12: 680. Doi.org/10.3390/antiox12030680.

Prasanth MI, Sivamaruthi BS, Chaiyasut C, Tencomnao T (2019). “A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy.” Nutrients 11: 474. Doi:10.3390/nu11020474.

Proksch E, de Bony R, Trapp S, Boudon S (2017). “Topical use of dexpanthenol: a 70th anniversary article.” J Dermatol Treatment 28(8): 766-773.

Scott LN, Fiume M, Bergfield WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks Jr JG, Shank RC, Slaga TJ, Snyder PW, Heldreth B (2022). “Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics.” Int J Toxicol 41(3_suppl): 77-128.

Soma Y, Kashima M, Imaizumi A, Takhama H, Kawakami T, Mizoguchi M (2005). “Moisturizing effects of topical nicotinamide on atopic dry skin.” Int J Dermatol 44: 197-202.

Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S (2008). “Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier.” British J Dermatol 143(3): 524-531.

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