Full Follicle Advanced Scalp Serum

A bottle typically provides 30–60 applications (1–2 months), depending on coverage area.

In our independent third-party clinical trials, the majority saw visible results within 30 days and 100% saw results by 60 days with continued improvement by 120 days.

We pride ourselves on making highly effective products. Many scalp serums only contain one or two actives (or actives that do not work), but ours contains several scientifically studied actives across several different classes and mechanisms to comprehensively address the causes of thinning hair.

Research suggests peptide Acetyl-Tetrapeptide 3, a Growth Factor complex of 5 synergistic GFs (IGF-1, aFGF, bFGF, EGF, VEGF), and Swiss apple stem cells with a high level of procyanidins stimulate dormant hair follicles to enter into active growth and extend the growth stage. Caffeine and Red clover counter-act hormonal effects of DHT on hair follicle miniaturization. Ginseng, Rosemary, and Eucalyptus stimulate blood flow. Vitamins biotin (B7) and panthenol (B5) promote the health and survival of hair follicle cells

Signal peptides are also known as Matricin or Matrikine peptides and specifically refer to collagen or extracellular matrix (ECM) fragments which improve wrinkles and skin hydration by signaling fibroblasts to increase the production of collagen, elastin, glycosaminoglycans (GAGs) such as hyaluronic acid, and other components of the ECM including proteoglycans, fibronectin and laminin (Errante et al. 2020, Gorouhi and Maibach 2009).

Matrixyl 3000 is a patented combination of two signal peptides (pal-GHK and pal-GQPR, aka palmitoyl tripeptide-7 and palmitoyl tripeptide-1) which have known synergy with one another as first demonstrated in in-vitro studies with dermal fibroblasts (fibroblasts secrete collagen, elastin, and other ECM components in the dermal layer of the skin) (US patent 2004/0132667 A1). In these studies, the combination of pal-GHK and pal-GQPR was more effective at stimulating collagen type 1, fibronectin and hyaluronic acid than either peptide alone.

Subsequent placebo controlled clinical studies in both men and women showed that a cream containing Matrixyl 3000 significantly decreased wrinkle depth and volume as well as skin roughness. In the first clinical study in older women, Matrixyl 3000 cream was applied on half the face versus placebo on the other half for crow’s feet wrinkles. With Matrixyl 3000, they found a significant 23.3% decrease in wrinkle volume, a 19.9% decrease in wrinkle depth and 16% decrease in roughness compared to baseline but no benefit with placebo. In the second clinical study in older men, Matrixyl 3000 cream gel was applied on half the face versus placebo on the other half on crow’s feet wrinkles. With Matrixyl 3000, they found a significant 17.1% decrease in wrinkle volume and 10.2% decrease in wrinkle depth and 8.4% decrease in roughness compared to baseline but no benefit with placebo (Sederma Matrixyl 3000).

A final clinical study was conducted to image changes of the papillary dermis. As described in a follow-up US patent 2012/164488, Sederma conducted a double-blind, placebo-controlled clinical study in 28 women who applied Matrixyl 3000 on half the face and placebo on the other half for 2 months and found an improvement in dermal density and reduced fragmentation in the collagen fibers of the dermis with Matrixyl 3000 compared to placebo (Sederma Matrixyl 3000).

On their own, pal-GHK and pal-GQPR also represent two of the best studied signal peptides. As characteristic of signal peptides, GHK and GQPR are fragments of proteins found naturally in the human body that are involved in ECM remodeling particularly during wound healing. GHK is a fragment of the alpha 2 chain of type I collagen while GQPR is a fragment of immunoglobin G. By linking each of these peptides to a palmitoyl group (and hence the pal-), these peptides become lipophilic. In other words, being lipophilic, they can cross the stratum corneum, the waterproof outer layer of the skin barrier, and can be absorbed into the deeper layers of the skin where they have their action.

GHK was first isolated from human plasma in 1973 (Pickart and Thaler 1973) and its wound repair properties were first observed in 1985 by Maquart and colleagues who found GHK was a potent activator of ECM synthesis and remodeling (Maquart et al. 1999). GHK has been found since then to have multiple biological actions improving tissue repair in skin, lung connective tissue, boney tissue, liver, and stomach lining. It has a wide range of effects on gene expression (Pickart and Margolina 2018). When damage activates proteolytic enzymes, GHK is released into the site of injury. GHK can stimulate skin dermal fibroblasts to produce growth factors and increase collagen synthesis and epidermal basal cells increasing integrins and p63 expression (Pickart and Margolina 2018, Lintner 2002).

GHK content is highest in the young with plasma levels at about ~200ng/ml at age 20 which declines to ~80ng/ml at age 60. This natural decline with aging may in part explain why adding peptides back to the skin can reverse signs of aging. GHK has been used in anti-aging and cosmetic products in humans for decades without any adverse effects and so has an established safety record (Pickart and Margolina 2018). Even without co-formulation with pal-GQPR, pal-GHK can increase collagen and GAG synthesis as well as improve collagen repair (Sederma Matrixyl 3000).

There is some misinformation on the web that states signal peptides such as GHK that are involved in wound healing have negative effects such as increasing inflammation because they mimic wounds. This is untrue as GHK has proven anti-inflammatory and antioxidant activity. GHK has anti-inflammatory benefits by reducing TNF-alpha induced secretion of proinflammatory cytokine IL-6 in dermal fibroblasts, and GHK is an efficient antioxidant, inactivating damaging free radical by-products of lipid peroxidation (Pickart et al. 2015, Pickart and Margolina 2018).

Pal-GQPR has also been studied and used separately from pal-GHK for many years in both skin and eye creams. GQPR is a fragment of immunoglobin G which is immunomodulatory. As skin ages, there is an increase in inflammatory cytokine IL-6, which may contribute to chronic inflammation in the aging process. The putative mechanism by which Pal-GQPR works is by reducing IL-6 secretion by keratinocytes. However, like GHK, GQPR changes the expression of multiple genes and so it has a broad effect on fibroblast activity that goes beyond anti-inflammatory action. Studies by Sederma show that pal-GQPR and pal-GHK activate complementary genes explaining the synergy between the two peptides (Sederma Matrixyl 3000).

Yes. Androgenic alopecia affects both males and females. In females, the thinning of hair will be to a lesser extent and in a differing pattern as males. In both cases, this is due to increases in a hormone called dihydrotestosterone (DHT).

Caffeine and Red clover have been shown to directly counteract the effects of DHT in hair follicles. Growth factors and Swiss apple stem cell has also been found to be effective as treatments for androgenic alopecia.

In theory, it very well could. Many of the mechanisms that are thought to underlie hair loss due to GLP-1 medications are mechanisms targeted by the actives in the Full Follicle serum. However, this is currently an area of new and active study for which there is a lack of research and further study is needed.

You will get good results with the scalp serum only. However, for best results, we recommend using the entire 3-step system to experience fuller, healthier hair from root to tip. The advanced scalp actives in our serum are infused into our shampoo and conditioner.

Furthermore, our shampoo and conditioner are free of sulfates, silicones and build-up culprits to allow for maximum penetration of actives into the scalp and hair. Our conditioner is designed to nourish hair from the inside with butters and vitamins that penetrate into the hair shaft.

It can help men as well. As discussed, the Full Follicle line can help with male pattern baldness (androgenic alopecia) and promote a thicker and denser head of hair for both women and men.

This scalp serum is also recommended for men who have had recent hair transplantation as newly transplanted hair is subject to the same hormonal and aging factors that led to hair thinning in the first place.

No. This moisturizing hyaluronic acid based serum is designed to hydrate your scalp. 100% of subjects in our clinical study reported greater scalp hydration by 60 days. It’s thin texture helps it penetrate into pores when massaged in - without leaving a sticky residue.

Ease of use and lightweight texture was often mentioned by our beta testers. However, this serum is not designed to treat scalp issues such as dandruff and seborrheic dermatitis.

As your hair follicles revert back to their former state, your hair thickness and density will revert to its former state after a few months of discontinued usage.